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KMID : 0370219640080030076
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Yakhak Hoeji
1964 Volume.8 No. 3 p.76 ~ p.79
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Urinary Metabolites of p-Methoxycinnamic Acid
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우원식/Woo WS
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Abstract
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The metabolism of p-methoxycinnamic acid (p-MCA) has been studied in man and rabbits. Possible compounds were examined for metabolites by crystalization and bv paper chromatography, which excreted alter administration of p-MCA by stomach tube and intravenous injection. p-Methoxyhippuric acid was isolated from urine. Although pure glucuronide was not crystallized from urine, product was obtained by basic lead salt method, which gave p-methoxybenzoic acid (p-MBA) on hydrolysis and gave an intense naphthoresorcinol reaction. No evidence for the demethylation of p-MCA was found. These results are indicating that p-MCA may be mainly converted to p-MBA by beta-oxidation and excreted as its conjugates with glycine and glucuronic acid. Its oxidation does not appear to be dependent on intestinal micro-organisms.
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KEYWORD
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